Fix for UK region is to edit file PlutoDownload.py in folder usr/lib/enigma2/pyton/Plugins/Extensions/PlutoTV and change ip address "uk": "185.86.151.11", to "uk": "185.199.220.58",. Reboot box and it should work again
X_FORWARDS = {
"us": "185.236.200.172",
"uk": "185.86.151.11",
..,
..,
..,
}